Anti-Neurogranin Monoclonal Antibody (CBP3940)

Product Overview

Description

Neurogranin (NRGN) is the main postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. It is suggested that the NRGN is a direct target for thyroid hormone in the human brain, and that the control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. Neurogranin in CSF has been implicated as a possible marker for synaptic degeneration in Alzheimer's disease.

Immunogen

KLH conjugated peptide corresponding to residues 52-78 of human NRGN.

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP3940

Applications

IHC-P; WB; ELISA; IP

Application Notes

IHC (0.5-5.0 µg/mL); WB (1.0-10.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

1.0 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Neurogranin

Official Name

NRGN

Full Name

neurogranin (protein kinase C substrate, RC3)

Alternative Names

Neurogranin (Protein Kinase C Substrate; RC3)

Gene ID

4900(Human); 64011(Mouse); 64356(Rat)

Uniprot ID

Q92686(Human); P60761(Mouse); Q04940(Rat)

References

1. Diez-Guerra FJ. 2010. IUBMB Life. 62(8): 597. (PubMed)
2. De Vos A, et al. 2016. J Alzheimers Dis. 53(4): 1523. (PubMed)
3. De Vos A. et al. 2015. Alzheimers Dement. 11(12):1461. (PubMed)

Publications