NoGeneST™ Anti-OSM Aptamer, Truncated aOSM aptamer-1 sodium

Name: NoGeneST™ Anti-OSM Aptamer, Truncated aOSM aptamer-1 sodium
SKU: NRYF-0625-HZ22
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ22]

A minimized RNA aptamer that potently and selectively antagonizes the human cytokine Oncostatin M (OSM).

Target:: OSM

Type:: RNA

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Product Overview

Description

This is a truncated, or minimized, version of a parent anti-OSM RNA aptamer. It is engineered to contain the core nucleotide sequence essential for high-affinity binding to human Oncostatin M (OSM). The purpose of truncation is often to improve the therapeutic profile, enhance synthesis efficiency, and reduce production costs while fully retaining the biological function of blocking the OSM/gp130 receptor signaling pathway.

Type

RNA

Properties

Size

1 mg; 5 mg; 10 mg

Appearance

Supplied as a lyophilized white to off-white solid.

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

OSM

Full Name

Oncostatin M

Gene ID

5008

Uniprot ID

P13725

Target Overview

Oncostatin M (OSM) is a pleiotropic cytokine that belongs to the interleukin-6 (IL-6) family of signaling proteins. It plays a complex role in regulating a wide range of cellular processes, including inflammation, hematopoiesis (blood cell formation), and tissue remodeling. OSM exerts its effects by signaling through receptor complexes that contain the gp130 protein subunit. Due to its potent pro-inflammatory activities, OSM is considered a key mediator in the pathology of chronic inflammatory conditions, making it a significant target for therapeutic development.

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