NoGeneST™ Anti-OSM Aptamer, aOSM aptamer-1 sodium

Name: NoGeneST™ Anti-OSM Aptamer, aOSM aptamer-1 sodium
SKU: NRYF-0625-HZ21
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ21]

A potent and selective RNA aptamer that functions as an antagonist of the human cytokine Oncostatin M (OSM).

Target:: OSM

Type:: RNA

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Product Overview

Description

This is an engineered RNA aptamer designed to bind with high affinity and specificity to human Oncostatin M (OSM). By binding directly to the cytokine, the aptamer blocks OSM's ability to engage with its cell surface receptor subunit, gp130. This action effectively neutralizes OSM-mediated signaling pathways, which are implicated in the pathogenesis of various inflammatory diseases such as rheumatoid arthritis.

Type

RNA

Properties

Size

1 mg; 5 mg; 10 mg

Appearance

Supplied as a lyophilized white to off-white solid.

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

OSM

Full Name

Oncostatin M

Gene ID

5008

Uniprot ID

P13725

Target Overview

Oncostatin M (OSM) is a pleiotropic cytokine that belongs to the interleukin-6 (IL-6) family of signaling proteins. It plays a complex role in regulating a wide range of cellular processes, including inflammation, hematopoiesis (blood cell formation), and tissue remodeling. OSM exerts its effects by signaling through receptor complexes that contain the gp130 protein subunit. Due to its potent pro-inflammatory activities, OSM is considered a key mediator in the pathology of chronic inflammatory conditions, making it a significant target for therapeutic development.

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