NoGeneST™ Anti-PSEN1 Aptamer, aPSEN1 aptamer

Name: NoGeneST™ Anti-PSEN1 Aptamer, aPSEN1 aptamer
SKU: NRYF-0625-HZ85
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ85]

Aptamer designed to specifically recognize Presenilin-1, the catalytic core of the gamma-secretase complex implicated in Alzheimer's disease.

Target:: PSEN1

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Product Overview

Species

Human

Relevant Diseases

Alzheimer's Disease

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

PSEN1

Full Name

Presenilin-1

Gene ID

5663

Uniprot ID

P49768

Target Overview

Presenilin-1 is a multi-pass transmembrane protein that forms the catalytic core of the gamma-secretase complex, an intramembrane protease. This complex is responsible for cleaving the transmembrane domains of numerous proteins, most notably the Amyloid Precursor Protein (APP) after it has been initially processed by enzymes like BACE1. This final cleavage by the Presenilin-1-containing complex is what generates the various species of Amyloid-beta (Aβ) peptides. Mutations in the PSEN1 gene are the most common cause of early-onset, inherited Alzheimer's disease, directly impacting Aβ production and underscoring its central role in the disease's pathology.

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