SCN1A shRNA Plasmid Expression Vector Set

Name: SCN1A shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY339
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY339]

Target:: SCN1A

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Product Overview

Description

A crucial kit for the specific knockdown of the SCN1A gene (Nav1.1 sodium channel), the primary cause of Dravet syndrome. The set includes three distinct shRNA plasmid vectors targeting SCN1A mRNA for potent silencing, along with a scrambled shRNA plasmid as a negative control. It is vital for modeling SCN1A haploinsufficiency and studying its impact on neuronal excitability.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

SCN1A

Full Name

Sodium Channel Protein Type 1 Subunit Alpha

Alternative Names

Nav1.1; NAC1

Gene ID

6323

Uniprot ID

P35498

Target Overview

The SCN1A gene codes for the alpha subunit of the Nav1.1 voltage-gated sodium channel. This channel is a key component in the brain for initiating and propagating action potentials, particularly in inhibitory interneurons. By controlling the flow of sodium ions, SCN1A plays a crucial role in regulating neuronal excitability and maintaining the proper balance between excitation and inhibition in the central nervous system. Loss-of-function mutations in the SCN1A gene are the primary cause of Dravet syndrome, a severe form of pediatric epilepsy, and are associated with a spectrum of other seizure disorders.

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