Creative Biolabs

Rat Anti-IL-10 Monoclonal Antibody (N2A5), Unconjugated

[CAT#: NAB2007FY886]

Rat Monoclonal [N2A5] to IL-10

Host Species:
Rat
Species Reactivity:
Mouse
Applications:
ELISA; FC; IHC-Fr; WB

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Description
The rat anti-Mouse Interleukin-10 antibody, recognizes mouse inhibitor of cytokine synthesis (CSIF), also known as interleukin 10 (IL-10). IL-10 is produced by B cells expressing Ly-1 (CD5) (O'Garra et al., 1992) and a portion of stimulated T cells (Asseman et al., 1999). IL-10 has a wide range of biological properties, including inhibition of cytokine synthesis mediated by macrophages and T helper cells, and inhibition of delayed-type hypersensitivity. According to reports, rat anti-mouse IL-10 antibody clone JES5-2A5 can neutralize the activity of murine IL-10.
Immunogen
Recombinant mouse IL-10.
Species Reactivity
Mouse
Clonality
monoclonal
Host Species
Rat
Isotype
IgG1
Clone Number
N2A5
Applications
ELISA; FC; IHC-Fr; WB
Application Notes
ELISA: 1/200-1/2000
WB: 1/1000
FC: 1/10-1/100
Relevant Diseases
Amyotrophic Lateral Sclerosis; Frontotemporal Dementia
Conjugation
Unconjugated
Form
Liquid
Formulation
PBS, 0.09% Sodium Azide
Preservatives
YES
Concentration
1 mg/ml
Purification
Protein G
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
IL-10
Official Name
IL10
Full Name
Interleukin 10
Alternative Names
Interleukin 10
Gene ID
3586(Human)
Uniprot ID
P22301(Human)
1. Abrams, J.S. et al. (1992) Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples.
2. Sander, B. et al. (1993) Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen. Cytokine detection by immunoassay and intracellular immunostaining.
3. Nishigori, C. et al. (1998) HindIII liposomes suppress delayed-type hypersensitivity responses in vivo and induce epidermal IL-10 in vitro.
For Research Use Only. Not For Clinical Use.
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