Product
Cathepsin K Inhibitor Screening Kit (Fluorometric), Human
[CAT#: NK1120FY072]
Only kit on the market to screen Cathepsin K inhibitors
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Overview
Description
Cathepsin K (CTSK, EC 3.4.22.38) is a lysosomal cysteine protease involved in bone remodeling and resorption by osteoclasts. In addition, it also degrades collagen, gelatin and elastin. Our cathepsin K inhibitor screening kit utilizes the ability of active cathepsin K to cleave AFC-based synthetic peptide substrates to release AFC, which can be easily quantified using a fluorometer or fluorescent microplate reader. In the presence of cathepsin K-specific inhibitors, the cleavage of this substrate is reduced/eliminated, resulting in a reduction or complete loss of AFC fluorescence. This simple and high-throughput adaptability assay kit can be used to screen/research/characterize potential inhibitors of cathepsin K.
Screen/study/characterize potential inhibitors of Cathepsin K.
Screen/study/characterize potential inhibitors of Cathepsin K.
Species Reactivity
Human
Relevant Diseases
Neurological Disorders
Properites
Detection Method
Fluorescence (Ex/Em = 400/505 nm)
Assay Type
ELISA kit
Components
• CTSK Reaction Buffer
• CTSK Reagent
• Cathepsin K (Human)
• CTSK Substrate, Ac-LR-AFC (10 mM)
• CTSK Inhibitor (FF-FMK, 1 mM)
• CTSK Reagent
• Cathepsin K (Human)
• CTSK Substrate, Ac-LR-AFC (10 mM)
• CTSK Inhibitor (FF-FMK, 1 mM)
Preparation and Storage
Shipping
Dry Ice
Storage
-80°C
Research Use Only
For research use only
Target Details
Publications
Publications (0)
Neural Antibodies
Kits
For Research Use Only. Not For Clinical Use.
