Chronic Social Defeat Stress (CSDS) Model Development Service

Are you currently facing challenges in developing accurate animal models that reflect the complexities of human psychiatric disorders? Our chronic social defeat stress (CSDS) model development service helps you accelerate drug discovery by providing a validated, comprehensive, and scalable platform for preclinical research. We achieve this through our expert protocol design and detailed behavioral phenotyping, ensuring your drug candidates are tested on a highly translatable model.

The CSDS model development service is a powerful tool for advancing drug discovery in the field of neuropsychiatry. Rooted in a highly-regarded animal paradigm, the CSDS model induces a persistent, depression-like phenotype in rodents, closely mimicking the psychological and physiological impacts of prolonged social stress in humans. The model's ability to segregate subjects into susceptible and resilient phenotypes provides a unique opportunity to study the neurobiological underpinnings of vulnerability and resilience to stress.

Workflow Advantages Available Models Related Services FAQs

How CSDS Model Development Service Can Assist Your Project

At Creative Biolabs, our CSDS model development service is designed to deliver a robust and reliable platform for your preclinical studies. We provide more than just a model; we deliver a complete solution from animal preparation to final data analysis, enabling you to gain actionable insights into your drug candidates' efficacy. Our expertise ensures that you receive the highest quality data, allowing you to confidently progress your research.

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Workflow

Our workflow is a comprehensive, multi-stage process designed for clarity and scientific rigor, ensuring seamless integration with your research pipeline.

Workflow of our Stress-Induced Depression Mouse Models Development Services. (Creative Biolabs Original)

Required Starting Materials	To initiate a CSDS project, clients typically provide a detailed project plan outlining their specific research goals, the compound or therapeutic agent to be tested, and any custom dosing or administration requirements.
Final Deliverables	Upon project completion, you will receive a comprehensive final report, which includes raw behavioral data files, detailed statistical analyses, and a summary of key findings and conclusions.
Estimated Timeframe	The typical timeframe for a standard CSDS study, including all behavioral assessments, ranges from 4 to 6 weeks, though this can vary depending on the complexity of the drug administration schedule and the number of compounds being tested.

Why Choose Us?

Choosing CBL for your CSDS model development service gives you access to an unparalleled combination of expertise, validated methodologies, and a commitment to scientific excellence. Our approach ensures that your research benefits from the highest standards of reliability and translatability.

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Customer Reviews

"Using CBL's CSDS model development service in our research has significantly improved the reproducibility of our stress-induced depression studies." — Dr. Je Tr, Research Director

"The inclusion of a female CSDS model has been a game-changer for our work. The data from CBL's service has been consistent, allowing us to confidently explore sex-specific therapeutic targets." — Ma Jn, Principal Investigator

"CBL's comprehensive final report and detailed behavioral analysis saved us countless hours of in-house work and provided the critical data we needed to move forward with our lead candidate." — Dr. Sh Bn, Senior Scientist

Chronic Social Defeat Stress (CSDS) Model

The CSDS model is a robust and ethologically valid animal paradigm that induces a persistent, depression-like phenotype in mice through repeated social subordination. Unlike models that rely on non-specific physical or pharmacological stressors, CSDS simulates a naturalistic social environment where a smaller "intruder" mouse is subjected to brief, daily aggressive encounters with a larger, dominant "aggressor" mouse. Following the confrontation, the mice are housed in the same cage, separated by a perforated divider, ensuring prolonged visual, auditory, and olfactory exposure that perpetuates a state of heightened psychological stress.

This approach provides exceptional translational value due to its high face, construct, and predictive validity:

Validity	Description
Face Validity	The induced behavioral and physiological deficits—including anhedonia, heightened anxiety, social-avoidance behavior, reduced activity in an open field, and impaired performance in long-term memory tests—closely mimic the core symptoms of Major Depressive Disorder and PTSD in humans.
Construct Validity	The model is underpinned by key neurobiological changes observed in human stress-related disorders, such as alterations in the mesolimbic dopamine system (specifically the VTA-NAc circuit), dysregulation of the HPA axis, and inflammation-related signaling.
Predictive Validity	The CSDS-induced phenotypes are consistently reversed by chronic administration of clinically effective antidepressants. The model's flexibility allows for the evaluation of both chronic and acute antidepressant treatments, as well as client-specified dosing programs, providing unparalleled predictive value for your drug candidates.

Related Services

Our expertise in the CSDS model is part of a broader suite of services designed to accelerate your neuroscience research. To achieve your project goals, you may also be interested in:

Target Identification & Validation
Compound Screening & Profiling
Pharmacokinetic/Pharmacodynamic (PK/PD) Studies
Neuroinflammation Research Models

FAQs

Q Can your CSDS model be used to test acute treatments?

A While the CSDS model is particularly powerful for evaluating chronic treatments, its flexibility allows for the assessment of acute treatments as well. We can work with you to design a study that tests the immediate or rapid-acting effects of your compound, providing valuable data on its mechanism and potential clinical use.

Q How can I be sure the model is right for my specific drug candidate?

A Our team of experts is ready to assist you. We encourage a preliminary consultation to discuss your compound, its intended target, and your research goals. We will then recommend a tailored CSDS protocol that aligns with your specific needs, ensuring the model is a perfect fit for your project.

We are ready to provide detailed information, answer your questions, and discuss your specific project needs.

Contact Our Team for More Information and to Discuss Your Project.

For Research Use Only. Not For Clinical Use.

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