FUS shRNA Plasmid Expression Vector Set

Name: FUS shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY344
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY344]

Target:: FUS

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Inquiry

Product Overview

Description

An effective kit for the specific knockdown of the Fused in Sarcoma (FUS) gene, whose mutations cause familial ALS. The set contains three validated shRNA plasmid vectors targeting different sequences of the FUS mRNA, accompanied by a non-targeting scrambled shRNA plasmid as a negative control. It is an essential tool for investigating the mechanisms by which FUS mutations lead to motor neuron death.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

FUS

Full Name

TAR DNA-Binding Protein 43

Alternative Names

TDP43

Gene ID

23435

Uniprot ID

Q13148

Target Overview

TAR DNA-binding protein 43 (TDP-43) is a highly conserved protein that primarily resides in the nucleus and is critically involved in RNA processing, including transcription, alternative splicing, and mRNA stability. TDP-43 is most notable for its central role in neurodegenerative diseases. In nearly all cases of Amyotrophic Lateral Sclerosis (ALS) and over half of the cases of Frontotemporal Lobar Degeneration (FTLD), TDP-43 becomes pathologically altered. It mislocalizes from the nucleus to the cytoplasm, becomes hyperphosphorylated and ubiquitinated, and aggregates into insoluble inclusions within neurons. This "proteinopathy" is a defining pathological hallmark of these diseases.

Publications