MOG shRNA Plasmid Expression Vector Set

Name: MOG shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY348
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY348]

Target:: MOG

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Product Overview

Description

A specialized kit for the targeted knockdown of the Myelin Oligodendrocyte Glycoprotein (MOG) gene, a key autoantigen in demyelinating diseases like MS. The set includes three distinct shRNA plasmid vectors targeting MOG mRNA, plus a scrambled shRNA plasmid as a negative control. It allows researchers to study MOG's function and its role in autoimmune-mediated demyelination.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

MOG

Full Name

Survival Motor Neuron Protein

Alternative Names

SMNC

Gene ID

6607

Uniprot ID

Q16637

Target Overview

SMN2 is a gene that is nearly identical to SMN1. However, a critical single nucleotide difference causes most of the mRNA transcribed from the SMN2 gene to be improperly spliced, resulting in the exclusion of a key section (exon 7). This leads to the production of a truncated and unstable protein that is largely non-functional. In patients with Spinal Muscular Atrophy (SMA) who lack a functional SMN1 gene, the SMN2 gene is their only source of SMN protein. The severity of the disease often correlates with the number of SMN2 gene copies a person has. This makes SMN2 the primary therapeutic target for SMA, with major treatment strategies focused on modulating its splicing to increase the production of full-length, functional protein.

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