Mouse Anti-ATRX Monoclonal Antibody (AB151)

Neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease and Huntington's disease The result of the gradual loss of neuron structure and function, Causes neuron death. The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]

Human

Monoclonal

Mouse

IgG1

AB151

IHC; WB; IF

IHC: 1:200-1:500
WB: 1 µg/ml
IF: 2-10 µg/ml

Alzheimer's Disease; Huntington's Disease; Parkinson's Disease; Amyotrophic Lateral Sclerosis

Liquid

PBS, pH 7.2, 40% glycerol

0.02% Sodium azide

1 mg/ml

Protein A purified

Gel Pack

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

The antibody solution should be gently mixed before use.

For research use only

ATRX

ATRX

ATRX, Chromatin Remodeler

ATRX, Chromatin Remodeler; ATP-Dependent Helicase ATRX; X-Linked Nuclear Protein; X-Linked Helicase II; ZNF-HX; RAD54L; XH2; XNP; Alpha Thalassemia/Mental Retardation Syndrome X-Linked (RAD54 (S. Cerevisiae) Homolog); Alpha Thalassemia/Mental Retardation Syndrome X-Linked (RAD54 Homolog, S. Cerevisiae); Alpha Thalassemia/Mental Retardation Syndrome X-Linked

546(Human); 22589(Mouse); 246284(Rat)

P46100(Human); Q61687(Mouse); P70486(Rat)