Creative Biolabs

Mouse Anti-ATRX Monoclonal Antibody (AB151)

[CAT#: NAB2007FY1706]

Amyotrophic Lateral Sclerosis,
Parkinson's, Alzheimer's and Huntington's diseases

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC; WB; IF

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Description
Neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease and Huntington's disease The result of the gradual loss of neuron structure and function, Causes neuron death. The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1
Clone Number
AB151
Applications
IHC; WB; IF
Application Notes
IHC: 1:200-1:500
WB: 1 µg/ml
IF: 2-10 µg/ml
Relevant Diseases
Alzheimer's Disease; Huntington's Disease; Parkinson's Disease; Amyotrophic Lateral Sclerosis
Form
Liquid
Formulation
PBS, pH 7.2, 40% glycerol
Preservatives
0.02% Sodium azide
Concentration
1 mg/ml
Purification
Protein A purified
Shipping
Gel Pack
Storage
Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling Advice
The antibody solution should be gently mixed before use.
Research Use Only
For research use only
Target
ATRX
Official Name
ATRX
Full Name
ATRX, Chromatin Remodeler
Alternative Names
ATRX, Chromatin Remodeler; ATP-Dependent Helicase ATRX; X-Linked Nuclear Protein; X-Linked Helicase II; ZNF-HX; RAD54L; XH2; XNP; Alpha Thalassemia/Mental Retardation Syndrome X-Linked (RAD54 (S. Cerevisiae) Homolog); Alpha Thalassemia/Mental Retardation Syndrome X-Linked (RAD54 Homolog, S. Cerevisiae); Alpha Thalassemia/Mental Retardation Syndrome X-Linked
Gene ID
546(Human); 22589(Mouse); 246284(Rat)
Uniprot ID
P46100(Human); Q61687(Mouse); P70486(Rat)
For Research Use Only. Not For Clinical Use.
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