NeuroMab™ Mouse Anti-Galectin-3 Binding Protein Monoclonal Antibody (CBP1936)

Description

Mouse anti-human galectin-3 binding protein antibody can recognize galectin-3 binding protein, also known as L3 antigen, MAC2BP, Mac-2-binding protein, basement membrane autoantigen p105, lectin and galactoside binding soluble 3- Binding protein, mac -2 BP, serum protein 90K, transport and Golgi tissue 10 homolog B and tumor-associated antigen 90K.
Galectins are a family of β-galactoside-binding proteins, which are involved in regulating cell-cell and cell-matrix interactions. Galectin-3 binding protein has been found to be elevated in the serum of cancer patients and in the serum of patients infected with human immunodeficiency virus (HIV). It seems to be related to the immune response related to the cytotoxicity of natural killer (NK) and lymphokine activated killer (LAK) cells. Using fluorescence in situ hybridization, the full-length 90K cDNA has been mapped to chromosome 17q25. The natural protein specifically binds to a lectin associated with human macrophages called Mac-2, and also binds to galectin-1 (provided by RefSeq, July 2008).
The mouse anti-human galectin-3 binding protein antibody can detect a band of 75 kDa. The antibody has been extensively validated by Western blot using whole cell lysates.

Immunogen

A recombinant protein corresponding to amino acids 19-300 of human galectin 3 binding protein (NP_005558) produced in E. coli

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP1936

Applications

WB

Application Notes

WB (1/1000)

Relevant Diseases

Lou Gehring's Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1573

Form

Liquid

Formulation

PBS; 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol

Preservatives

Yes

Purification

Affinity chromatography from tissue culture supernatant.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Gal-3BP

Official Name

LGALS3BP

Full Name

galectin 3 binding protein

Alternative Names

90K; M2BP; gp90; CyCAP; BTBD17B; MAC-2-BP; TANGO10B

Gene ID

3959(Human); 19039(Mouse); 245955(Rat)

Uniprot ID

Q08380(Human); Q07797(Mouse); O70513(Rat)