Product
Mouse Anti-EAAT2 Monoclonal Antibody (CBP2270)
[CAT#: NAB2010196LS]
Anti-EAAT2 Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
EAAT2 is the major membrane protein that clears extracellular glutamate from the synaptic area to prevent potential neuronal excitotoxicity from excessive activation of glutamate receptors. EAAT2 is predominantly expressed in the central nervous system on astrocytes and is frequently used as a marker for these cells. Mutations that affect EAAT2 function are clinically associated with amyotrophic lateral sclerosis.
Immunogen
Partial recombinant mouse SLC1A2 (EAAT2) protein (a.a. 143 - 238) with GST Tag
Species Reactivity
Human; Mouse; Rat
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2b, κ
Clone Number
CBP2270
Applications
WB
Application Notes
WB (0.5-10 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Handling Advice
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
References
1. Pregnolato S, et al. 2019. Front Physiol. 10:417
2. Parkin GM, et al. 2018. World J Psychiatry. 10.5498/wjp.v8.i2.51
3. Rosenblum LT, Trotti D. 2017. Adv. Neurobiol. 16:117-136.
2. Parkin GM, et al. 2018. World J Psychiatry. 10.5498/wjp.v8.i2.51
3. Rosenblum LT, Trotti D. 2017. Adv. Neurobiol. 16:117-136.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
