Mouse Anti-EAAT2 Monoclonal Antibody (CBP2270)

Product Overview

Description

EAAT2 is the major membrane protein that clears extracellular glutamate from the synaptic area to prevent potential neuronal excitotoxicity from excessive activation of glutamate receptors. EAAT2 is predominantly expressed in the central nervous system on astrocytes and is frequently used as a marker for these cells. Mutations that affect EAAT2 function are clinically associated with amyotrophic lateral sclerosis.

Immunogen

Partial recombinant mouse SLC1A2 (EAAT2) protein (a.a. 143 - 238) with GST Tag

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP2270

Applications

Application Notes

WB (0.5-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

EAAT2

Official Name

SLC1A2

Full Name

Excitatory amino acid transporter 2

Alternative Names

SLC1A2; EAAT2; GLT-1; HBGT; solute carrier family 1 member 2; EIEE41

Gene ID

6506(Human); 20511(Mouse); 29482(Rat)

Uniprot ID

P43004(Human); P43006(Mouse); P31596(Rat)

References

1. Pregnolato S, et al. 2019. Front Physiol. 10:417
2. Parkin GM, et al. 2018. World J Psychiatry. 10.5498/wjp.v8.i2.51
3. Rosenblum LT, Trotti D. 2017. Adv. Neurobiol. 16:117-136.

Publications