Product
Mouse Anti-Human P2Y12 Monoclonal Antibody (CBP2421)
[CAT#: NAB2010497LS]
Anti-P2Y12 Monoclonal Antibody [FITC]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
P2RY12 is a receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system and is not activated by UDP and UTP. P2RY12 is required for normal platelet aggregation and blood coagulation, and is a target to inhibit of platelet aggregation in the treatment of thromboembolisms and other clotting disorders. P2RY12 is expressed on platelets, lung, appendix, pituitary and adrenal glands; this molecule is a very useful marker to identify microglial cells in the brain.
Immunogen
Human P2RY12-transfected cells
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2a, κ
Clone Number
CBP2421
Applications
FC
Application Notes
FCM (5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
FITC
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.
Concentration
Batch Dependent
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Handling Advice
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
References
1. Lecchi A, et al. 2015. Blood. 125:1006.
2. Zhang K, et al. 2014. Nature. 509:115.
3. Zhang J, et al. 2014. Nature. 509:119.
4. Cornelissen I, et al. 2010. Proc. Natl. Acad. Sci. USA. 107:18605.
5. Paruchuri S, et al. 2009. J. Exp. Med. 206:2543.
2. Zhang K, et al. 2014. Nature. 509:115.
3. Zhang J, et al. 2014. Nature. 509:119.
4. Cornelissen I, et al. 2010. Proc. Natl. Acad. Sci. USA. 107:18605.
5. Paruchuri S, et al. 2009. J. Exp. Med. 206:2543.
Publications
Publications (0)
Neural Antibodies
Neural Assays
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
