Rat Anti-IL-6 Monoclonal Antibody (CBP2543)

Product Overview

Description

Rat anti-Mouse Interleukin-6 antibody, recognizes mouse Interleukin 6 (IL-6), also known as B-cell hybridoma growth factor or Interleukin HP-1. IL-6 is an effective lymphoid cell growth factor mainly expressed by macrophages and T cells. IL-6 is an effective inducer of acute phase reactions. Animals lacking IL-6 show a significant reduction in pro-inflammatory Th17 cell production (Ivanov et al., 2006). In humans, the disruption of IL-6 gene may lead to the appearance of systemic juvenile rheumatoid arthritis (RASJ), which is an inflammatory joint disease characterized by daily episodes of fever, macular rash, lymphadenopathy, liver and spleen Swelling, serositis, myalgia and arthritis.

Immunogen

Recombinant mouse IL-6.

Species Reactivity

Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG1

Clone Number

CBP2543

Applications

ELISA

Relevant Diseases

Amyotrophic Lateral Sclerosis; Frontotemporal Dementia

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.09% Sodium Azide

Preservatives

YES

Concentration

0.5 mg/ml

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

IL-6

Official Name

IL6

Full Name

Interleukin 6 (IL-6)

Alternative Names

IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6

Gene ID

3569(Human)

Uniprot ID

P05231(Human)

References

1. Abrams, J.S. et al. (1992) Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples.
2. Kambayashi, T. et al. (1995) Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-alpha and IL-6 release by endotoxin-stimulated macrophages.
3. Vankelecom, H. et al. (1993) Immunocytochemical evidence that S-100-positive cells of the mouse anterior pituitary contain interleukin-6 immunoreactivity.
4. Skok, J. et al. (1999) Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation: a feedback regulation of Th1 development.

Publications