Product Overview

Description

The rat anti-Mouse MARCO antibody, recognizes the mouse cell surface antigen called MARCO (macrophage receptor with collagen structure), which is a member of the class A scavenger receptor family. MARCO is expressed by different populations of macrophages in the spleen and lymph nodes, but is rapidly induced on macrophages in other tissues (eg liver Kupffer cells) during infection or LPS treatment. The rat anti-Mouse MARCO antibody, clone ED31, binds to the C-terminal cysteine-rich domain of MARCO and has been shown to block ligand binding.

Immunogen

CHO cells expressing mouse MARCO.

Species Reactivity

Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG1

Clone Number

CBP2588

Applications

WB; IHC-Fr; IF

Application Notes

IHC-Fr: 1/200-1/400

Relevant Diseases

Alzheimer's Disease; Neurodegenerative Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.09% Sodium Azide

Preservatives

YES

Concentration

1 mg/ml

Purification

Protein G

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Marco

Official Name

Marco

Full Name

Macrophage Receptor With Collagenous Structure

Alternative Names

Macrophage Receptor With Collagenous Structure; Scavenger Receptor Class A, Member 2; SCARA2; Scavenger Receptor Class A Member 2; Macrophage Receptor MARCO; SR-A6;

Gene ID

8685(Human); 367391(Rat)

Uniprot ID

Q9UEW3(Human)

References

1. van der Laan, L.J. et al. (1997) Macrophage scavenger receptor MARCO: in vitro and in vivo regulation and involvement in the anti-bacterial host defense.
2. Dioszeghy, V. et al. (2008) 12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo.
3. Devey, L. et al. (2009) Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism.
4. Hsu, K.M. et al. (2009) Murine cytomegalovirus displays selective infection of cells within hours after systemic administration.

Publications