Mouse Anti-GATA1 Monoclonal Antibody (CBP2596)

Product Overview

Description

GATA1, a zinc finger DNA-binding transcription factor, plays a critical role in the normal development of hematopoietic cell lineages. The protein contains an N-terminal region that confers transcriptional activity and a C-terminal domain that mediates binding to DNA and other factors [PMID: 8524811]. GATA-1 is also implicated in regulating the expression of the erythroid and megakaryocytic-specific genes.

Expression Host

Mammalian cells

Immunogen

GATA1 fusion protein Ag1350

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2596

Applications

FC; WB; ELISA

Application Notes

WB : 1:500-1:1000

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

GATA1

Official Name

GATA1

Full Name

GATA binding protein 1 (globin transcription factor 1)

Alternative Names

ERYF1; Erythroid transcription factor; GATA 1; GATA binding factor 1; GATA1; GF 1; GF1; NF E1 DNA binding protein

Gene ID

2623(Human)

Uniprot ID

P15976(Human)

References

1. Yu, W., Huang, W., Yang, Y., Qiu, R., Zeng, Y., Hou, Y.,... & Chen, Y. (2019). GATA3 recruits UTX for gene transcriptional activation to suppress metastasis of breast cancer. Cell death & disease, 10(11), 1-16. 2. Chen, J., Li, X. B., Su, R., Song, L., Wang, F., & Zhang, J. W. (2014). ZNF16 (HZF1) promotes erythropoiesis and megakaryocytopoiesis via regulation of the c-KIT gene. Biochemical Journal, 458(1), 171-183. 3. Wu, J., Zhou, L. Q., Yu, W., Zhao, Z. G., Xie, X. M., Wang, W. T.,... & Zhang, P. (2014). PML4 facilitates erythroid differentiation by enhancing the transcriptional activity of GATA-1. Blood, 123(2), 261-270.

Publications