Mouse Anti-C3 Monoclonal Antibody (CBP2703)

Product Overview

Description

The complement system is an important effector which bridges the innate and adaptive immune systems (PMID: 20010915). The third component of complement, C3, plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways (PMID: 11414361). Human C3, composed of α and β chains (115 and 75 kDa, respectively), is cleaved into C3a and C3b by C3 convertase. C3b is further cleaved into iC3b, C3c, C3dg and C3f. This antibody raised against 1314-1663 aa of human C3 protein recognize C3 alpha chain, C3b alpha' chain, and C3c alpha' chain fragment 2.

Expression Host

Mammalian cells

Immunogen

C3/C3b/C3c fusion protein Ag15955

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2703

Applications

IF; IHC; WB; ELISA

Application Notes

IF : 1:20-1:200; IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neurotransmitter

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

353 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Official Name

Full Name

Complement component 3

Alternative Names

ARMD9; ASP; C3; C3b; C3c; Complement C3; complement component 3; CPAMD1

Gene ID

718(Human); 12266(Mouse); 24232(Rat)

Uniprot ID

P01024(Human); P01027(Mouse); P01026(Rat)

References

1. Zou, Y., Gong, P., Zhao, W., Zhang, J., Wu, X., Xin, C.,... & Li, X. (2019). Quantitative iTRAQ-based proteomic analysis of piperine protected cerebral ischemia/reperfusion injury in rat brain. Neurochemistry international, 124, 51-61.

Publications