Mouse Anti-GRIN2B Monoclonal Antibody (CBP2802)

Product Overview

Description

GRIN2B is a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. NMDA receptors are widely expressed in the central nervous system and play a major role in excitatory synaptic transmission and plasticity (PMID: 23223336). NMDA receptors large multi-subunit complexes arranged into heteromeric assemblies composed of four homologous subunits within a repertoire of over 10 different subunits: eight GluN1 isoforms, four GluN2 subunits (A-D) and two GluN3 subunits (A and B) (PMID: 21395862). Naturally occurring mutations within GRIN2B gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.

Expression Host

Mammalian cells

Immunogen

NMDAR2B/GRIN2B fusion protein Ag16718

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2802

Applications

WB; ELISA

Application Notes

WB : 1:500-1:1000

Research Areas

Metabolism

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

660 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

GRIN2B

Official Name

GRIN2B

Full Name

Glutamate receptor, ionotropic, N-methyl D-aspartate 2B

Alternative Names

AW490526;
EIEE27;
Glutamate [NMDA] receptor subunit epsilon 2;
Glutamate [NMDA] receptor subunit epsilon-2;
Glutamate Receptor Ionotropic N Methyl D Aspartate 2B;
Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B;

Gene ID

2904(Human); 14812(Mouse); 24410(Rat)

Uniprot ID

Q13224(Human); Q01097(Mouse); Q00960(Rat)

References

1. Xu, X., Jiang, S., Xu, E., Wu, X., & Zhao, R. (2019). Inhibition of CB1 receptor ameliorates spatial learning and memory impairment in mice with traumatic brain injury. Neuroscience Letters, 696, 127-131. 2. Wen, Y., Wu, K., Xie, Y., Dan, W., Zhan, Y., & Shi, Q. (2019). Inhibitory effects of glucagon-like peptide-1 receptor on epilepsy. Biochemical and biophysical research communications, 511(1), 79-86. 3. Kool, M. J., Onori, M. P., Borgesius, N. Z., van de Bree, J. E., Elgersma-Hooisma, M., Nio, E.,... & Elgersma, Y. (2019). CAMK2-dependent signaling in neurons is essential for survival. Journal of Neuroscience, 39(28), 5424-5439.

Publications