Mouse Anti-OPA1 Monoclonal Antibody (CBP2807)

Product Overview

Description

OPA1 is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. OPA1 localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. OPA1 is associated with the inner membrane and protects cells from apoptosis by regulating inner membrane dynamics. Mutation of OPA1 causes the disease dominant optic atrophy, a degeneration of the retinal ganglion cells. OPA1 undergoes complex posttranscriptional regulation and posttranslational proteolysis. OPA1 is regulated by proteolytic cleavage, which degrades long OPA1 isoforms into short isoforms.

Expression Host

Mammalian cells

Immunogen

OPA1 fusion protein Ag26868

Species Reactivity

Human; Mouse; Porcine; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP2807

Applications

WB; ELISA

Application Notes

WB : 1:500-1:1000

Research Areas

Growth and Development

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

OPA1

Official Name

OPA1

Full Name

Optic atrophy 1

Alternative Names

Antigen KI 67; Ki 67; KI67; KIA; MKI83

Gene ID

4976(Human); 74143(Mouse); 171116(Rat)

Uniprot ID

O60313(Human); P58281(Mouse); Q2TA68(Rat)

References

1. Mazaki, Y., Takada, S., Nio-Kobayashi, J., Maekawa, S., Higashi, T., Onodera, Y., & Sabe, H. (2019). Mitofusin 2 is involved in chemotaxis of neutrophil-like differentiated HL-60 cells. Biochemical and biophysical research communications, 513(3), 708-713. 2. Si, L., Liu, W., Hayashi, T., Ji, Y., Fu, J., Nie, Y.,... & Ikejima, T. (2019). Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment. Archives of biochemistry and biophysics, 671, 42-51. 3. Xu, Z., Jin, X., Pan, T., Liu, T., Wan, N., & Li, S. (2017). Antagonistic effects of selenium on cadmium-induced apoptosis by restoring the mitochondrial dynamic equilibrium and energy metabolism in chicken spleens. Oncotarget, 8(32), 52629.

Publications