Mouse Anti-ERC1 Monoclonal Antibody (CBP2827)

Product Overview

Description

ERC is an acronym based on previous separate namings of members of this protein family, ELKS, Rab6IP2 and CAST (PMID: 12391317). They are known to bind RIMs, the active zone proteins that regulate neurotransmitter release. ERC1 (ELKS) is an essential regulatory subunit of the IKK complex and likely functions by recruiting IκBα to the complex (PMID: 15218148). Multiple isoforms of ERC1 mRNA are generated by alternative splicing (PMID: 12203787). There are two known splice variants of ERC1 protein that differ at their C termini, ERC1a and ERC1b. ERC1a is ubiquitously expressed, whereas ERC1b is brain-specific.

Expression Host

Mammalian cells

Immunogen

ERC1 fusion protein Ag17665

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2827

Applications

WB; ELISA

Application Notes

WB : 1:500-1:1000

Research Areas

Metabolism

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

ELKS

Official Name

ERC1

Full Name

ELKS/RAB6-interacting/CAST family member 1

Alternative Names

Cast 2;
CAST2;
CAZ associated structural protein 2;
Elks;
ELKS/RAB6 interacting/CAST family member 1;
ELKS/RAB6-interacting/CAST family member 1;
ERC 1;
ERC protein 1;
ERC-1;
Erc1;

Gene ID

23085(Human); 111173(Mouse); 266806(Rat)

Uniprot ID

Q8IUD2(Human); Q99MI1(Mouse); Q811U3(Rat)

References

1. Fourriere, L., Kasri, A., Gareil, N., Bardin, S., Bousquet, H., Pereira, D.,... & Miserey-Lenkei, S. (2019). RAB6 and microtubules restrict protein secretion to focal adhesions. Journal of Cell Biology, 218(7), 2215-2231. 2. Liu, Q., Liu, F., Yu, K. L., Tas, R., Grigoriev, I., Remmelzwaal, S.,... & Akhmanova, A. (2016). MICAL3 flavoprotein monooxygenase forms a complex with centralspindlin and regulates cytokinesis. Journal of Biological Chemistry, 291(39), 20617-20629. 3. Liu, Q., Remmelzwaal, S., Heck, A. J., Akhmanova, A., & Liu, F. (2017). Facilitating identification of minimal protein binding domains by cross-linking mass spectrometry. Scientific reports, 7(1), 1-11.

Publications