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Creative Biolabs

Mouse Anti-Human PLAP Monoclonal Antibody (CBP3683)

[CAT#: NAB201215LS]

Anti-PLAP Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC-P; WB

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Product Overview

Description

PLAP is a membrane-bound glycosylated dimeric enzyme that was initially identified in the placenta. PLAP is also known as phospholipase A2 activating protein. Abnormal amyloid beta-induced activation of synaptic phospholipase A2 results in synaptic degeneration due to elevated levels of platelet-activating factor, suggesting that PLAP may be a contributing factor in synaptic damage observed in Alzheimer's disease patients. Clinically, PLAP is broadly used as a tumor marker, especially in geminoma, seminoma, and ovarian cancer.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP3683

Applications

IHC-P; WB

Application Notes

IHC (2.0-10 µg/ml); WB (0.5-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated
Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

PLAP

Official Name

ALPP

Full Name

Placental alkaline phosphatase

Alternative Names

ALPP; ALP; PALP; PLAP; PLAP-1; alkaline phosphatase; placental; ALPI; IAP

Gene ID

250 (Human); 76768 (Mouse)

Uniprot ID

P05187 (Human); F8VPQ6 (Mouse)
Publications

Publications (0)

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For Research Use Only. Not For Clinical Use.
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