Anti-VPS35 Monoclonal Antibody (CBP3723)

Product Overview

Description

VPS35 is the largest subunit of the retromer complex, which plays an important role in retrograde protein transport from the endosome to the trans-Golgi network. VPS35 binds to VPS26 (VPS26A or VPS26B) and VPS29 to form the vacuolar protein sorting subcomplex (VPS), which in turn interacts with different nexins to form different retromer variants that transport different targets. D620N mutation in VPS35 has been implicated as a causative genetic factor for developing late-onset, autosomal dominant familial Parkinson's disease, and could serve as potential therapeutic target for PD.

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP3723

Applications

Application Notes

WB (1.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

VPS35

Official Name

VPS35

Full Name

VPS35

Alternative Names

VPS35; Vacuolar protein sorting 35 homolog

Gene ID

100133770(Human); 65114(Mouse); 25479(Rat)

Uniprot ID

Q96QK1(Human); Q9EQH3(Mouse)

References

1. Cui Y, et al. 2018. FEBS Lett. 592(7):1096
2. Williams ET, et al. 2017. J Parkinsons dis. 7(2):219
3. Ferreira M, et al. 2017. Acta Neurol Scand. 135(3):273

Publications