Mouse Anti-Human Rab7 Monoclonal Antibody (CBP3737)

Product Overview

Description

Alzheimer's disease is characterized by the accumulation of aggregated Aβ peptides in senile plaques and vascular deposits. Aβ peptides are derived from amyloid precursor proteins (APP) through sequential proteolytic cleavage of APP by β-secretases and γ-secretases generating diverse Aβ species. Aβ can aggregate to form soluble oligomeric species and insoluble fibrillar or amorphous assemblies. Some forms of the aggregated peptides are toxic to neurons.

Immunogen

Human amyloid beta fibrils

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP3737

Applications

IHC-P; WB

Application Notes

IHC-P (0.5-10 µg/mL); WB (2.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

RAb7A

Official Name

RAB7A

Full Name

Rab7

Alternative Names

RAB7A; PRO2706; RAB7; member RAS oncogene family; CMT2B

Gene ID

7879 (Human); 19349 (Mouse)

Uniprot ID

P51149 (Human); P51150 (Mouse)

References

1. Kumar A, et al. 2015. Pharmacol Rep. 67(2):195.
2. Sadigh-Eteghad S, et al. 2015. Med Princ Pract. 24(1):1
3. Hampel H, et al. 2015. Expert Rev Neurother. 15(1):83.
4. Puig KL & Combs CK. 2012. Exp Gerontol. 48(7): 608.
5. Selkoe DJ & Hardy J. 2016. EMBO Mol Med. 8(6):595.
6. Walsh DM, et al. 2007. J Neurochem. 101(5):1172.

Publications