Anti-PER1 Monoclonal Antibody (CBP3767)

Product Overview

Description

PER1 (Period Circadian Regulator 1), a transcriptional repressor, is a component of the circadian clock and a member of the Period family. PER1 is expressed throughout peripheral tissues but expression is most significant in the suprachiasmatic nucleus (SCN) region of the brain which functions as the primary circadian pacemaker in mammals. PER1 is expressed in an oscillating rhythm with a period of about 24 hours which is maintained even in constant darkness.

Immunogen

Partial recombinant human PER1

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2a, κ

Clone Number

CBP3767

Applications

WB; IP

Application Notes

WB (0.0625-1.0 µg/mL); IHC-P (2.5 µg/test)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

PER1

Official Name

PER1

Full Name

Period Homolog 1

Alternative Names

Period Homolog 1

References

1. Gery S, et al. 2006. Mol Cell. 22:3:375.
2. Chen S, et al. 2005. Carcinogenesis. 26:7:1241.
3. Yan L, et al. 1999. Neuroscience. 94:1:141.
4. Shigeyoshi Y, et al. 1997. Cell. 91:7:1043.

Publications