Anti-CD354 Monoclonal Antibody (CBP3782)
[CAT#: NAB2012205LS]
Anti-CD354 Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human; African green monkey; Baboon; Cynomolgus; Rhesus
- Applications:
- FC; ELISA; WB
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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SPECIFIC INQUIRY
inquiryProduct Overview
Description
TREM-1 is a 30 kD glycoprotein, also known as a trigger receptor expressed on myeloid cells 1 and a trigger receptor expressed on monocytes 1. It is a type I membrane protein that contains an immunoglobulin-like V-type domain. Alternatively, spliced protein variants can be secreted. TREM-1 is highly expressed in peripheral blood bone marrow cells (especially mature monocytes and granulocytes); bacteria, fungi and lipopolysaccharides can further up-regulate the expression of TREM-1. TREM-1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines. TREM-1 is believed to enhance the inflammatory response to fungal and bacterial infections and enhance septic shock. This antibody has been shown to be useful for flow cytometry and to activate monocytes and granulocytes.
Immunogen
Recombinant human TREM-1
Species Reactivity
Human; African green monkey; Baboon; Cynomolgus; Rhesus
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1, κ
Clone Number
CBP3782
Applications
FC; ELISA; WB
Application Notes
FCM (5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
Batch Dependent
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
CD354
Official Name
TREM-1
Full Name
Triggering receptor expressed on myeloid cells 1
Alternative Names
TREM-1
References
1. Bouchon A, et al. 2001. Nature 410:1103.
2. Bouchon A, et al. 2000. J. Immunol. 164:4991.
3. Gingras MC, et al. 2002. Mol. Immunol. 38:817.
2. Bouchon A, et al. 2000. J. Immunol. 164:4991.
3. Gingras MC, et al. 2002. Mol. Immunol. 38:817.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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