Anti-CD354 Monoclonal Antibody (CBP3781)
[CAT#: NAB2012202LS]
Anti-CD354 Monoclonal Antibody [Biotin]
- Host Species:
- Mouse
- Species Reactivity:
- Human; African green monkey; Baboon; Cynomolgus; Rhesus
- Applications:
- FC; ELISA; ICC; IHC
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Lot Number
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Lot Number
SPECIFIC INQUIRY
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Description
TREM-1 is a 30 kD glycoprotein, also known as a trigger receptor expressed on myeloid cells 1 and a trigger receptor expressed on monocytes 1. It is a type I membrane protein that contains an immunoglobulin-like V-type domain. Alternatively, spliced protein variants can be secreted. TREM-1 is highly expressed in peripheral blood bone marrow cells (especially mature monocytes and granulocytes); bacteria, fungi and lipopolysaccharides can further up-regulate the expression of TREM-1. TREM-1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines. TREM-1 is believed to enhance the inflammatory response to fungal and bacterial infections and enhance septic shock. This antibody has been shown to be useful for flow cytometry and to activate monocytes and granulocytes.
Immunogen
Recombinant human TREM-1
Species Reactivity
Human; African green monkey; Baboon; Cynomolgus; Rhesus
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1, κ
Clone Number
CBP3781
Applications
FC; ELISA; ICC; IHC
Application Notes
FCM (5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Alexa Fluor 594; Alexa Fluor 488; Alexa Fluor 498; Alexa Fluor 647; Alexa Fluor 700; APC; APC/Cyanine 7; APC/Fire 750; Biotin; Brilliant Violet 421; Brilliant Violet 510; Brilliant Violet 570; Brilliant Violet 570; Brilliant Violet 605; Brilliant Violet 650; Brilliant Violet 711; Brilliant Violet 750; Brilliant Violet 785; FITC; HRP; PE; Pacific Blue; PE/Cyanine 5; PE/Cyanine 7; PerCP; Spark YG 570
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.
Concentration
Batch Dependent
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
CD354
Official Name
TREM-1
Full Name
Triggering receptor expressed on myeloid cells 1
Alternative Names
TREM-1
References
1. Bouchon A, et al. 2001. Nature 410:1103.
2. Bouchon A, et al. 2000. J. Immunol. 164:4991.
3. Gingras MC, et al. 2002. Mol. Immunol. 38:817.
2. Bouchon A, et al. 2000. J. Immunol. 164:4991.
3. Gingras MC, et al. 2002. Mol. Immunol. 38:817.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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