Mouse Anti-Human CD271 Monoclonal Antibody (CBP3941)

Product Overview

Description

CD271, also known as p75NTR, TNFRSF16, p75 (NTR), Gp80-LNGFR and NGFR, is a type I transmembrane protein with a molecular weight of 75 kD. It is expressed by many cell types, including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells and melanocytes. The extracellular part contains four TNFR-Cys repeats, which form the binding domain of its ligands (NGF, BDNF, NTF3 and NTF4). The intracellular part of CD271 contains a death domain that interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9 to promote cell apoptosis and regulate cell differentiation and neurogenesis.

Immunogen

This monoclonal antibody was raised against A875 human myeloma cells and p75NTR purified from A875 human myeloma cells.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG

Clone Number

CBP3941

Applications

IHC-P

Application Notes

IHC-P (1.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

1.0 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD271

Official Name

NGFR

Full Name

Nerve growth factor receptor

Alternative Names

CD271; Gp80 LNGFR; NGF receptor; NGFR; p75; p75 ICD; p75(NTR); p75NTR; TNFRSF16

Gene ID

4804(Human); 18053(Mouse); 24596(Rat)

Uniprot ID

P08138(Human); Q9Z0W1(Mouse); P07174(Rat)

References

1. Friedman MJ, et al. 2009. J. Biol. Chem. 284:27944.
2. Rock JR, et al. 2009. Proc Natl Acad Sci USA. 106:12771.
3. Kidd SK, et al. 2008. Brain Res.1195:113.
4. Peters EM, et al. 2007. Am J Pathol. 171:1872.
5. Jansen P, et al. 2007. Nat Neurosci. 10:1449.

Publications