Mouse Anti-Human CD141 Monoclonal Antibody (CBP3983)
[CAT#: NAB2012928LS]
Anti-CD141 Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB; ELISA; IHC-P
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
CD141 is a 75 kD single-chain type I membrane glycoprotein, also known as thrombomodulin, TM, THRM, THBD and fetal regulatory protein. CD141 is an important cofactor in the protein C anticoagulation system. After binding to its ligand thrombin, CD141 activates protein C, which degrades coagulation factors Va and Villa, thus reducing the amount of thrombin. CD141 is expressed on macrophages, monocytes, bone marrow dendritic cell subsets, vascular endothelial cells and keratinocytes. In addition to its anticoagulant function, CD141 is also involved in the development of embryos and atherosclerotic plaques. CD141 is an endothelial cell surface glycoprotein involved in blood coagulation regulation. Through direct interaction with thrombin, thrombomodulin can lead to down-regulation of multiple procoagulant pathways to preserve the anticoagulant properties of the endothelial cell surface.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2
Clone Number
CBP3983
Applications
WB; ELISA; IHC-P
Application Notes
WB (1:500-1:1000); ELISA (1:1000); IHC (1:100)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.
Concentration
1.0 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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