Mouse Anti-SPP1 Monoclonal Antibody (CBP4058)

Description

Human osteopontin (OPN) is a negatively charged 314 amino acid hydrophilic protein that undergoes major post-translational modifications (PTM), including phosphorylation and glycosylation. Due to its acidity and PTM, OPN It runs abnormally through SDS-PAGE. The mass is 35kD, and the apparent molecular weight may be as high as 75kD. In addition, OPN will be proteolytically modified into smaller molecular weight fragments. The stromal cell protein osteopontin binds to cell surface receptors and secretes many In bodily fluids, including milk, blood and urine, osteopontin is easily obtained from secretions and mimics the cellular environment in which it is released, making osteopontin an ideal candidate for biomarkers. Osteopontin plays a role in immune response and Inflammation is also important. In children with autism, the level of serum osteopontin is related to the severity of the disease may be caused by inflammation in the brain of these children. In aortic valve sclerosis and stenosis, secretion is also noted The level of osteopontin is increased. Osteopontin is also considered a biomarker of cancer because it is related to tumor formation, progression and metastasis. During the formation of bones and teeth, osteopontin is a parathyroid hormone A negative regulator of related protein receptors can induce bone formation. Without proper levels of osteopontin, bone growth will continue to be uncontrolled and lead to specific bone cancer. In short, osteopontin is bone growth and inflammation And a powerful marker of certain cancers. The newly exposed SVVYG epitope on the N-terminal fragment also appears to be involved in cell adhesion.

Immunogen

Recombinant full-length human osteopontin

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP4058

Applications

WB; ELISA

Application Notes

The optimal conditions should be determined individµally.

Conjugation

Unconjugated

Form

colorless liquid

Formulation

0.15 M PBS

Preservatives

BSA free

Purification

Protein A

Shipping

Gel Pack

Storage

-20°C

Handling Advice

The antibody solution should be gently mixed before use.

Target

SPP1

Official Name

SPP1

Full Name

Secreted Phosphoprotein 1

Alternative Names

Secreted Phosphoprotein 1; Early T-Lymphocyte Activation 1; Urinary Stone Protein; Nephropontin; Osteopontin; Uropontin; BNSP; OPN; Secreted Phosphoprotein 1 (Osteopontin; Bone Sialoprotein I; Early T-Lymphocyte Activation 1)

Gene ID

6696(Human); 20750(Mouse)

Uniprot ID

P10451(Human); P10923(Mouse)