Mouse Anti-Human FAF1 Monoclonal Antibody (CBP4246)

Product Overview

Description

FAS-associated factor 1 (FAF1) is an evolutionarily conserved protein with multiple protein interaction domains, including a FAS-interacting domain (FID), a death effector domain interacting domain (DEDID), and multi-ubiquitin-related domains. Initially identified as a member of FAS death-inducing signaling complex, FAF1 plays diverse roles in apoptotic and survival pathways. It may also serve as a scaffolding protein that regulates protein degradation in the ubiquitin-proteasome pathway. FAF1 is abundantly expressed in the brain where it modulates cell death. FAF1 also serves as a substrate for parkin, a key protein implicated in the pathogenesis of Parkinson's disease (PD). Wild type parkin ubiquitinates FAF1 and promotes its degradation, while PD-linked mutant parkin causes abnormal accumulation of FAF1.

Immunogen

Recombinant full length protein

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP4246

Applications

Application Notes

WB (0.5-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

FAF1

Official Name

FAF1

Full Name

FAS-associated factor 1

Alternative Names

FAF1; HFAF1s; UBXD12; UBXN3A; hCGI-03; Fas associated factor 1

Gene ID

11124

Uniprot ID

Q9UNN5

References

1. Menges CW, et al. 2009. Cell Cycle. 8(16):2528-34.
2. Sul JW, et al. 2013. Hum Mol Genet. 22(8):1558-73.
3. Cheng K, et al. 2011. J Neurosci. 31(33):11905-13.

Publications