Mouse Anti-Human and Drosophila Gelsolin Monoclonal Antibody (CBP4248)

Product Overview

Description

After severing, gelsolin remains bound to the barbed end of the actin filament, preventing the reannealing of severed filaments. Gelsolin is crucial for the maintenance of actin homeostasis. Cells from gelsolin null mice exhibit a variety of defects, such as pronounced stress fibers formation, defective chemotaxis, and wound healing. Dysfunction of Gelsolin has been indicated in multiple diseases include cancer, infection, inflammation, cardiac injury, pulmonary disease, and neurodegeneration. Gelsolin is proteolytically cleaved and rendered inactive in Alzheimer's disease (AD). Overexpression of gelsolin significantly reduces amyloid beta load in brains of AD transgenic mice.

Immunogen

Recombinant full-length gelsolin protein

Species Reactivity

Human; Drosophila

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP4248

Applications

WB; IHC-P

Application Notes

WB (0.2-1.0 µg/mL); IHC-P (5-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

HRP

Product Properties

Form

Liquid

Formulation

This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Gelsolin

Official Name

GSN

Full Name

Gelsolin

Alternative Names

GSN; Gsn; ADF; AGEL; gelsolin

Gene ID

2934

Uniprot ID

P06396

References

1. Ji L, et al. 2015. J Alzheimers Dis. 44(1):13-25
2. Asch HL, et al. 1996. Cancer Res. 56(21):4841-5.
3. Sun HQ, et al. 1999. J Biol Chem. 274(47):33179-82.
4. Ji L, et al. 2009. J Alzheimers Dis. 18(1):105-11.

Publications