Mouse Anti-Human PRDX4 Monoclonal Antibody (CBP4249)

[CAT#: NAB210116LS]

Anti-PRDX4 Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Human

Applications:: WB

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Product Overview

Description

Peroxiredoxins (PRDXs) are a ubiquitously expressed small molecule family of proteins (22-27 kD) regulating peroxide reduction of H2O2 and cellular homeostasis. The protective role of PRDXs is well established in cardiovascular diseases, neurological disorders and cancers. PRDX4 is an ER enzyme that acts as a H2O2 sensor. In the brain, PRDX4 regulates neurogenesis via controlling the surface expression of glycerophosphodiester phosphodiesterase 2. In human glioblastomas, the expression of PRDX4 is markedly increased. In vitro, suppression of PRDX4 in glioblastoma cells induces apoptosis and reduces tumor growth.

Immunogen

Recombinant full length protein

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, κ

Clone Number

CBP4249

Applications

Application Notes

WB (2.5-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.