Rat Anti-Human HSPB6 Monoclonal Antibody (CBP4261)

Product Overview

Description

Heat shock protein B6 (HSPB6), or Hsp20, is a member of the conserved small heat shock protein family, which have important functions in protein folding and aggregation. HSPB6 is ubiquitously expressed, and is particularly enriched in skeletal, cardiac, smooth muscle tissue, and central nervous system. Like many other small heat shock proteins, HSPB6 functions as a molecular chaperone and its expression is up-regulated upon cellular stress conditions to protect cells and tissue from damage. HSPB6 is an important mediator in cardio protective signaling and functions in a BCL-2-associated anthanogene 3 (BAG3)-dependent manner. In multiple sclerosis (MS), HSPB6 level is markedly increased in astrocytes.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2a, κ

Clone Number

CBP4261

Applications

WB; IHC-P

Application Notes

WB (1.0-10 µg/mL); IHC-P (1.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

0.01 M PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

HSPB6

Official Name

HSPB6

Full Name

Heat shock protein beta-6

Alternative Names

HSPB6; HEL55; Hsp20; PPP1R91; heat shock protein family B (small) member 6

Gene ID

126393

Uniprot ID

O14558

References

1. Li F, et al. 2017. Cell Physiol Biochem. 44(1):314-332.
2. Fang X, et al. 2019. JCI Insight. 4(4). pii: 126464.
3. Peferoen LA, et al. 2015. Acta Neuropathol Commun. 3:87.

Publications