Mouse Anti-Human Optineurin Monoclonal Antibody (CBP4291)

Description

Optineurin (OPTN), also known as FIP-2 or NEMO-related protein (NRP), is a cytoplasmic protein associated with diverse cellular functions including membrane trafficking, vesicle transport, and cell cycle control. OPTN has also been identified as an autophagy receptor important in elimination of damaged mitochondria through mitophagy, a selective macroautophagy process. Mutations in the Optn gene have been linked to a variety of disorders including amyotrophic lateral sclerosis, glaucoma, and Paget's disease of bone. In vitro cellular studies suggest that optineurin recognizes various protein aggregates via its C-terminal coiled-coiled domain in a ubiquitin-independent manner and facilitates autophagic clearance of protein aggregates. Immunohistochemical analyses demonstrate the localization of OPTN to pathological tau tangles in Alzheimer's disease tissues, and Lewy bodies and neurites in Parkinson's disease tissues, supporting its role in neurodegenerative diseases.

Immunogen

Recombinant human optineurin protein

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, λ

Clone Number

CBP4291

Applications

WB; ICC

Application Notes

WB (2.0-10 µg/mL); ICC (2.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Optineurin

Official Name

OPTN

Full Name

Optineurin

Alternative Names

OPTN; ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA-INTP; optineurin

Gene ID

Uniprot ID

Q96CV9(Human); Q8K3K8(Mouse); Q8R5M4(Rat)