Mouse Anti-PTPRC Monoclonal Antibody (CBP6738)

Description

Neuroinflammation is locally produced in the central nervous system through phenotypic changes of different non-neuronal cell types (such as microglia, oligodendrocytes, and astrocytes) in the brain, leading to different cytokines and chemokines The release of C, eventually recruits and infiltrates peripheral blood cells, mainly T-and B cells, into the brain parenchyma. Protein tyrosine phosphatase, receptor type, C, also known as PTPRC, is an enzyme encoded by the PTPRC gene in humans. PTPRC is also called CD45 antigen (CD stands for differentiation cluster) and was originally called Leukocyte Common Antigen (LCA).

The protein product of this gene, most famously CD45, is a member of the protein tyrosine phosphatase (PTP) family. PTP is a signaling molecule that regulates various cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

CD45 is a type I transmembrane protein and exists in various isoforms in all differentiated hematopoietic cells (except red blood cells and plasma cells). CD45 has been shown to be an important regulator of T cell and B cell antigen receptor signal transduction. It plays a role by directly interacting with the components of the antigen receptor complex through its extracellular domain (a form of co-stimulation), or through its cytoplasmic domain to activate various Src family kinases required for antigen receptor signal transduction. CD45 can also inhibit JAK kinase, so it can be used as a negative regulator of cytokine receptor signal transduction.

Epitope

Binds to an located within the peptide sequence LNLDKNLIKY

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP6738

Applications

IHC; WB

Application Notes

IHC: 1:200-1:500
WB: 1 µg/ml

Marker

Glial Cell Markers; Microglia Markers

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

0.5 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

CD45

Official Name

PTPRC

Full Name

Protein tyrosine phosphatase, receptor type, C

Alternative Names

PTPRC; B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200; protein tyrosine phosphatase; receptor type C; protein tyrosine phosphatase receptor type C

Gene ID

5788 (Human); 19264 (Mouse)

Uniprot ID

P08575 (Human); P08575 (Mouse)