GRN shRNA Plasmid Expression Vector Set

Name: GRN shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY364
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY364]

Target:: GRN

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Product Overview

Description

A powerful tool for the specific knockdown of the Progranulin (GRN) gene, a major causal gene for frontotemporal dementia (FTD). The set includes three sequence-verified shRNA plasmid vectors, each targeting a different region of the GRN mRNA, and a non-targeting scrambled shRNA plasmid as a negative control. This kit is critical for modeling FTD and studying the role of progranulin in lysosomal function and neuroinflammation.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

GRN

Full Name

D(2) Dopamine Receptor

Gene ID

1813

Uniprot ID

P14416

Target Overview

The D2 dopamine receptor (DRD2) is a G protein-coupled receptor (GPCR) and one of the principal receptors for the neurotransmitter dopamine. It is highly expressed in the brain in pathways that are crucial for motor control, motivation, reward, and cognition. DRD2 plays a central role in neuropsychiatry as it is the primary pharmacological target for all typical and atypical antipsychotic drugs, which are used to treat schizophrenia and other psychotic disorders. The receptor is also critically implicated in the pathophysiology of Parkinson's disease and addiction.

Publications