Nrf2 shRNA Plasmid Expression Vector Set

Name: Nrf2 shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY358
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY358]

Target:: Nrf2

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Inquiry

Product Overview

Description

An essential kit for the targeted knockdown of the Nrf2 (NFE2L2) gene, the master regulator of the antioxidant response. The set provides three validated shRNA plasmid vectors targeting different sequences of the Nrf2 mRNA, along with a non-targeting scrambled shRNA plasmid as a negative control. It allows researchers to investigate the role of the Nrf2 pathway in neuroprotection and cellular defense.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

Nrf2

Full Name

Transient Receptor Potential Cation Channel Subfamily M Member 2

Alternative Names

TRPC7; LTRPC2

Gene ID

7226

Uniprot ID

O94759

Target Overview

Transient Receptor Potential Melastatin 2 (TRPM2) is a non-selective cation channel that functions as a crucial cellular sensor for oxidative stress. It is activated by intracellular ADP-ribose, which is produced under conditions of oxidative stress and DNA damage, leading to an influx of calcium (Ca2+) and other cations into the cell. By translating oxidative stress signals into changes in intracellular calcium levels, TRPM2 is involved in a wide range of physiological and pathological processes, including immune responses, insulin secretion, and programmed cell death. Its role in mediating neuronal death following ischemia makes it a target of interest for neuroprotective research.

Publications