Creative Biolabs

Human Anti-Mouse Apo E 109-116 Monoclonal Antibody (Clone A17067B), Unconjugated

[CAT#: NAB201275LS]

Anti-Apo E 109-116 Monoclonal Antibody

Host Species:
Human
Species Reactivity:
Mouse
Applications:
WB; ELISA; IHC-P

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Description
Apolipoprotein E (ApoE) belongs to a class of apolipoproteins, which combine with lipids to form lipoproteins. ApoE is produced by macrophages in the liver and peripheral tissues and can regulate cholesterol metabolism. In the central nervous system, ApoE is mainly produced by astrocytes and plays an important role in transporting cholesterol to neurons through ApoE receptors. ApoE has three main isoforms corresponding to the three alleles (ApoE2, ApoE3 and ApoE4), which differ by only one or two amino acids at positions 112 and 158. ApoE4 is known to be one of the largest genetic risk factors for advanced Alzheimer's disease. In addition, ApoE4 is also associated with several other diseases, such as atherosclerosis, cognitive impairment and multiple sclerosis.
Species Reactivity
Mouse
Clonality
Monoclonal
Host Species
Human
Isotype
IgG2b, κ
Clone Number
A17067B
Applications
WB; ELISA; IHC-P
Application Notes
WB (0.2-1.0 µg/mL); ELISA (0.004-0.4 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Apo E
Official Name
APOE
Full Name
Apolipoprotein E
Alternative Names
APOE; AD2; APO-E; LDLCQ5; LPG; apolipoprotein E; ApoE4
Gene ID
348 (Human); 11816 (Mouse)
Uniprot ID
P02649 (Human); P08226 (Mouse)
1. Mahley RW. 2016. Arterioscler Thromb Vasc Biol. 36: 1305-1315.
2. Riedel BC, et al. 2016 J Steroid Biochem Mol Biol. 160:134-47.
3. Tai LM, et al. 2016 Acta Neuropathol. 131(5):709-23.
4. Kim J, et al. 2014. Mol. Cells. 37:767
5. Holtzman DM, et al. 2012. Cold Spring Harb. Perspect. Med. 2:a006312
Neural Genes
Neural Antibodies
Kits
Neural Cell Lines
Neural Proteins & Peptides
For Research Use Only. Not For Clinical Use.
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