mGluR5 shRNA Plasmid Expression Vector Set

Name: mGluR5 shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY352
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY352]

Target:: mGluR5

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Product Overview

Description

A specialized kit for the specific knockdown of the Metabotropic Glutamate Receptor 5 (mGluR5) gene. The set provides three validated shRNA plasmid vectors targeting different sequences of the mGluR5 mRNA, along with a non-targeting scrambled shRNA plasmid as a negative control. It is a key tool for investigating Fragile X syndrome and the therapeutic potential of mGluR5 modulation.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

mGluR5

Full Name

SH3 And Multiple Ankyrin Repeat Domains Protein 3

Gene ID

85358

Uniprot ID

Q9Y6A5

Target Overview

SHANK3 is a large scaffolding protein located at the postsynaptic density (PSD) of excitatory synapses within the brain. It functions as a master organizer by anchoring and connecting neurotransmitter receptors, ion channels, and signaling proteins to the underlying actin cytoskeleton. This structural role is essential for the proper development, maturation, and plasticity of synapses. Disruption of the SHANK3 gene through mutation or deletion is one of the most common single-gene causes of Autism Spectrum Disorder (ASD) and is the defining genetic feature of Phelan-McDermid Syndrome, highlighting its critical role in brain development.

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