Product
Mouse Anti-Human HDAC8 Monoclonal Antibody (CBP3752)
[CAT#: NAB2012138LS]
Anti-HDAC8 Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ChIP; WB; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
HDAC8 is a kinectically and structurally well-characterized deacetylase that was reported to catalyze several nuclear proteins, which include ERR-α, hEST1B, and SMC3. Patients with HDAC8 mutations show Cornelia de Lange Syndrome (CdLS) and Wilson-turner Syndrome (WTS) phenotypes. Elevated expression of HDAC8 has been observed in various tumor types, such as acute lymphoblastic leukemia (AML), neuroblastomas, and glimoas. HDAC8 is implicated as a therapeutic target in cancer and infectious diseases.
Immunogen
Full length human HDAC8 recombinant protein expressed in E. coli.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1, κ
Clone Number
CBP3752
Applications
ChIP; WB; ICC
Application Notes
ChIP (1:50); WB (0.5-2.0 µg/mL); ICC (1.0-5.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
Batch Dependent
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
References
1. Qi J, et al. 2015. Cell Stem Cell. 17:597.
2. Tian Y, et al. 2015. Cancer Res. 75:4803.
3. Feng L, et al. 2015. J. Hum. Genet. 60:165.
4. Ha SD, et al. 2014. J. Immunol. 193:1333.
5. Higuchi T, et al. 2013. Blood 121:3640.
6. Deardorff MA, et al. 2012. Nature 489:313.
2. Tian Y, et al. 2015. Cancer Res. 75:4803.
3. Feng L, et al. 2015. J. Hum. Genet. 60:165.
4. Ha SD, et al. 2014. J. Immunol. 193:1333.
5. Higuchi T, et al. 2013. Blood 121:3640.
6. Deardorff MA, et al. 2012. Nature 489:313.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
