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NeuroMab™ Anti-PRNP BBB Shuttle Antibody,Clone NR1395P

[CAT#: NRZP-1022-ZP3589]

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IP; WB; ELISA; Inhib; In Vitro

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG

Clone Number

NR1395P

Applications

IP; WB; ELISA; Inhib; In Vitro

Relevant Diseases

Creutzfeldt-Jakob Disease
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

PRNP

Official Name

PRNP

Full Name

prion protein

Alternative Names

PRNP; ASCR; AltPrP; CD230; CJD; GSS; KURU; PRIP; PrP; PrP27-30; PrP33-35C; PrPc; p27-30; prion protein
Product Pictures
WB

Figure 1. Western blot of normal bovine brain homogenate and recombinant bovine PrP. mAb 6H4 and 34C9 recognize bovine PrP and rbPrP, whereas may 15B3 recognizes only rbPrP Recombinant rbPrP runs lower and more acutely than PrP from brain homogenate because it is not glycosylated.

WB

Figure 2 Epitope mapping of the bovine PrP peptide library.

mAB 34C9 recognizes peptides Nos. 59 to 63 of the peptide library comprising the epitopes of amino acids 149 to 153 (Leu Ile His Phe Gly) of bovine PrP.

WB

Figure 2 Epitope mapping of the bovine PrP peptide library.

mAB 6H4 recognizes peptides Nos. 64 to 66 of the peptide library comprising the epitopes of amino acids 155 to 163.

IP

Figure 3. Immunoprecipitation of bovine, mouse and human PrP using mAbs 15B3 and 6H4

Proteinase K digestion of immunoprecipitated PrP BSE using mA 15B3. Undigested and digested bovine brain homogenates were compared to immunoprecipitates digested with protein A-agarose only or proteinase K with 15B3.

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