Product
Mouse Anti-TIGIT Monoclonal Antibody (CBP2166)
[CAT#: NAB-2011-ZP154]
- Host Species:
- Mouse
- Species Reactivity:
- Mouse
- Applications:
- ELISA
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as VSTM3, is a type I transmembrane protein, which belongs to the PVR family of immunoglobulin-like domain containing proteins. It is composed of an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on activated T cells, follicular T helper, memory T cells, and regulatory T cells and NK cells. TIGIT binds to CD155 (PVR) with high affinity and it regulates T-cell mediated immunity via the CD226/TIGIT-PVR pathway. TIGIT also serves as a negative regulator of NK and T cell activation.
Species Reactivity
Mouse
Clonality
Monoclonal
Host Species
Mouse
Isotype
Mouse
Clone Number
CBP2166
Applications
ELISA
Application Notes
Working concentrations for specific applications should be determined by the investigators. The appropriate concentration may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined.
The following concentration ranges are recommended starting points for this product.
ELISA detection: 0.01-0.05 µg/ml
The following concentration ranges are recommended starting points for this product.
ELISA detection: 0.01-0.05 µg/ml
Product Properties
Concentration
0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
The lyophilized product remains stable up to 1 year at -20 °C from date of receipt. Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below. Avoid freeze/thaw cycles.
Handling Advice
Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/ml.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
TIGIT
Official Name
TIGIT
Full Name
T cell immunoreceptor with Ig and ITIM domains
Alternative Names
WUCAM; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9; VSIG9; VSTM3; T-cell immunoreceptor with Ig and ITIM domains
Data
 family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.)
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
