Mouse Anti-Human NFATc2 Monoclonal Antibody (CBP2189)

Product Overview

Description

NFATc2 is a family member of the NFAT (calcineurin-dependent nuclear factor of activated T cells) transcription factors, regulating expression of the genes involved in T-cell activation and proliferation. In resting T cells, NFATc2 protein is phosphorylated and is present in the cytoplasm. Upon stimulation, NFATc2 protein is dephosphorylated by calcium dependent phosphatase, resulting in the translocation of NFATc2 protein to the nucleus, where it induces expression of target genes. In addition to its roles in immune cells, NFATc2 is revealed to mediate VEGF signaling, transactivating the gene encoding cyclooxygenase 2 (COX2). The production of prostaglandins by cycloxoygenase 2 is required for the migration of endothelial cells and angiogenesis. NFATc2 is also suggested to participate in tumorigenesis and invasive migration of tumor cells.

Immunogen

N-terminal Peptide-KLH

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP2189

Applications

Application Notes

WB (2.0-4.0 µg./mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

NFATc2

Official Name

NFATC2

Full Name

Nuclear factor of activated T-cells, cytoplasmic 2

Alternative Names

NFATC2; NFAT1; NFATP; nuclear factor of activated T-cells 2; nuclear factor of activated T cells 2

Gene ID

4773 (Human); 10819 (Mouse)

Uniprot ID

Q13469 (Human); Q60591 (Mouse)

References

1. Gerlach K, et al. 2012. Cancer Res. 72:4340.
2. Ohoka Y, et al. 2011. J. Immunol. 186:733.
3. Nguyen TN, et al. 2010. Mol. Immunol. 47:2314.
4. Alev C, et al. 2009. Cell Cycle. 8:1803.
5. Becker M, et al. 2009. J. Immunol. 182:6136.
6. Horsley V, et al. 2002. J. Cell Biol. 156:771.

Publications