NeuroMab™ Mouse Anti-Human PARK7 / DJ1 Monoclonal Antibody (CBP2257)

Product Overview

Description

DJ-1 (PARK7) belongs to the peptidase C56 family of proteins and is expressed in almost all human cells and tissues. DJ-1 is a multi-functional protein associated with mitochondrial function, mitophagy, and male fertility. It acts as an oxidative stress sensor, redox-sensitive chaperone and protease. Therefore, the protein has an important role in cell protection against oxidative stress and cell death. DJ-1 is also associated with prostate cancer, and specific mutations of the protein are linked to autosomal recessive, early onset Parkinson's disease.

Immunogen

Recombinant Human DJ-1

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP2257

Applications

WB; IHC-P

Application Notes

WB (0.2-1.0 µg/mL); IHC (1.0-5.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1671

Product Properties

Form

Liquid

Formulation

This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Handling Advice

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

PARK7

Official Name

PARK7

Full Name

Protein deglycase DJ-1

Alternative Names

PARK7; DJ-1; DJ1; HEL-S-67p; Parkinsonism associated deglycase; GATD2

Gene ID

11315(Human); 57320(Mouse); 117287(Rat)

Uniprot ID

Q99497(Human); Q99LX0(Mouse); O88767(Rat)

References

1. Saito Y. 2014. J. Clin. Biochem. Nutr. 54(3):138-44. PubMed
2. Ariga H, et al. 2013. Oxid. Med. Cell Longev. 2013:683920. PubMed
3. Bonifati V, et al. 2003. Science (5604): 256-9. PubMed

Publications