PAPK7 shRNA Plasmid Expression Vector Set

Name: PAPK7 shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY335
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY335]

Target:: PARK7

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Product Overview

Description

A specialized kit for the specific suppression of the PARK7 (DJ-1) gene, linked to early-onset Parkinson's disease. The set contains three sequence-verified shRNA plasmid vectors targeting different regions of the PARK7 mRNA to ensure potent knockdown, along with a scrambled shRNA plasmid as a negative control. This tool is vital for studying PARK7's role in protecting neurons against oxidative stress.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

PARK7

Full Name

Parkinson Disease Protein 7

Alternative Names

Protein DJ-1 (DJ-1)

Gene ID

113115

Uniprot ID

Q99497

Target Overview

Protein deglycase DJ-1, also known as Parkinson disease protein 7 (PARK7), is a highly conserved and multifunctional protein that is crucial for protecting cells against oxidative stress. It functions as a redox-sensitive chaperone, an antioxidant, and a regulator of gene transcription. Its neuroprotective role is highlighted by the fact that loss-of-function mutations in the PARK7 gene are a direct cause of a rare form of early-onset, autosomal recessive Parkinson's disease. The protein's critical function in cellular defense mechanisms has made it a significant area of research for understanding the pathogenesis of Parkinson's and other neurodegenerative disorders.

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