Mouse Anti-NRP1 Monoclonal Antibody (CBP2606)

Product Overview

Description

NRP1 was first identified as a semaphorin (SEMA) receptor, involved in axonal guidance in embryonic development. NRP1 was also shown to act as a receptor for vascular endothelial growth factor (VEGF) and a promoter of angiogenesis through its interaction with VEGF-A165 (and other VEGFs) and the receptor tyrosine kinase (RTK) VEGF-R2. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.

Expression Host

Mammalian cells

Immunogen

Neuropilin 1 fusion protein Ag0931

Species Reactivity

Human; Porcine

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2606

Applications

FC; IF; WB; ELISA

Application Notes

IF : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Metabolism

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD304

Official Name

NRP1

Full Name

Neuropilin 1

Alternative Names

BDCA4; CD304; neuropilin 1; NRP; NRP1; VEGF165R

Gene ID

8829(Human); 18186(Mouse); 246331(Rat)

Uniprot ID

O14786(Human); P97333(Mouse); Q9QWJ9(Rat)

References

1. Zhang, L., Chen, Y., Li, C., Liu, J., Ren, H., Li, L.,... & Han, Z. (2019). RNA binding protein PUM2 promotes the stemness of breast cancer cells via competitively binding to neuropilin-1 (NRP-1) mRNA with miR-376a. Biomedicine & Pharmacotherapy, 114, 108772. 2. Duran, I., Tenney, J., Warren, C. M., Sarukhanov, A., Csukasi, F., Skalansky, M.,... & Krakow, D. (2018). NRP1 haploinsufficiency predisposes to the development of Tetralogy of Fallot. American Journal of Medical Genetics Part A, 176(3), 649-656. 3. Ma, L. L., Guo, L. L., Luo, Y., Liu, G. L., Lei, Y., Jing, F. Y.,... & Tang, M. S. (2020). Cdc42 subcellular relocation in response to VEGF/NRP1 engagement is associated with the poor prognosis of colorectal cancer. Cell death & disease, 11(3), 1-14.

Publications