Mouse Anti-Human Delta Opioid Receptor Monoclonal Antibody (CBP2301)

Product Overview

Description

Opioid receptors are the members of seven transmembrane G-protein coupled receptors. At least 3 types of opioid receptors, µ, κ, and δ, have been identified. Human δ-opioid receptor, know as OPRD, DOR, or hDOR, is primarily expressed in brain, especially in the areas of cortex, including olfactory bulb, hippocampus, and amygdale, as well as in basal ganglia and hypothalamus. Human OPRD gene has been mapped at chromosome 1p34.3-p36.1. The endogenous ligands for the OPRD are enkephalins. The third extracellular loop of the OPRD is critical for ligand binding. The ligands binding and signal transduction functions of δ-receptor can be synergized by forming heterodimers with κ-receptor. Activation of opioid receptor inhibits cAMP production, increases phosphodiesterase activity, and results in analgesia and convulsions. Recent studies have indicated that OPRD is involved in the mechanism of heroin dependence.

Immunogen

HEK-293/human Delta Opioid Receptor

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP2301

Applications

Application Notes

FCM (5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.

Concentration

Batch Dependent

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Delta Opioid Receptor

Official Name

OPRD1

Full Name

delta opioid receptor

Alternative Names

OPRD1; OPRD; Δ-opioid receptor; opioid receptor delta 1; DOP; DOR1; DOR

Gene ID

4985(Human); 18386(Mouse); 24613(Rat)

Uniprot ID

P41143(Human); P32300(Mouse); P33533(Rat)

References

1. Simonin F, et al. 1994. Mol. Pharmacol. 46:1015.
2. Befort K, et al. 1994. Genomics 20:143.
3. Bzdega T, et al. 1993. Proc. Nat. Acad. Sci. 90:9305.
4. Jordan BA. And LA Devi. 1999. Nature 399:697.
5. Xue K, et al. 2002. Am. J. Med. Genet. 11:45.

Publications