Product
Mouse Anti-Human Delta Opioid Receptor Monoclonal Antibody (CBP2301)
[CAT#: NAB2010246LS]
Anti-Delta Opioid Receptor Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- FC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Opioid receptors are the members of seven transmembrane G-protein coupled receptors. At least 3 types of opioid receptors, µ, κ, and δ, have been identified. Human δ-opioid receptor, know as OPRD, DOR, or hDOR, is primarily expressed in brain, especially in the areas of cortex, including olfactory bulb, hippocampus, and amygdale, as well as in basal ganglia and hypothalamus. Human OPRD gene has been mapped at chromosome 1p34.3-p36.1. The endogenous ligands for the OPRD are enkephalins. The third extracellular loop of the OPRD is critical for ligand binding. The ligands binding and signal transduction functions of δ-receptor can be synergized by forming heterodimers with κ-receptor. Activation of opioid receptor inhibits cAMP production, increases phosphodiesterase activity, and results in analgesia and convulsions. Recent studies have indicated that OPRD is involved in the mechanism of heroin dependence.
Immunogen
HEK-293/human Delta Opioid Receptor
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2b, κ
Clone Number
CBP2301
Applications
FC
Application Notes
FCM (5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.
Concentration
Batch Dependent
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Handling Advice
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
References
1. Simonin F, et al. 1994. Mol. Pharmacol. 46:1015.
2. Befort K, et al. 1994. Genomics 20:143.
3. Bzdega T, et al. 1993. Proc. Nat. Acad. Sci. 90:9305.
4. Jordan BA. And LA Devi. 1999. Nature 399:697.
5. Xue K, et al. 2002. Am. J. Med. Genet. 11:45.
2. Befort K, et al. 1994. Genomics 20:143.
3. Bzdega T, et al. 1993. Proc. Nat. Acad. Sci. 90:9305.
4. Jordan BA. And LA Devi. 1999. Nature 399:697.
5. Xue K, et al. 2002. Am. J. Med. Genet. 11:45.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
