Mouse Anti-Human Desmoglein 3 Monoclonal Antibody (CBP2302)

[CAT#: NAB2010247LS]

Anti-Desmoglein 3 Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Human

Applications:: WB; ICC

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Product Overview

Description

Desmoglein-3 is a glycoprotein mainly expressed in the basal lower layers of the epidermis and on mucosal surfaces. It is the Ca2+ binding transmembrane components of the desmosomes that functions as cell-cell junctions between epithelial cells as well as other cell types. Clinically, desmoglein-3 has been identified as one of the autoantigens in the autoimmune skin blistering disease pemphigus vulgaris. It also serves as a prognostic marker of esophageal squamous cell carcinoma.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP2302

Applications

WB; ICC

Application Notes

WB (0.5-1.0 µg/mL); ICC (2.0-10.0 μg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Desmoglein 3

Official Name

DSG3

Full Name

Desmoglein-3

Alternative Names

DSG3; CDHF6; PVA; desmoglein 3

Gene ID

1830 (Human); 13512 (Mouse)

Uniprot ID

P32926 (Human); O35902 (Mouse)

References

1. Mahmoudi H, et al. 2020. Int J Immunogenet. 47:41-9
2. Spindler V & Waschke J. 2018. Front immunol. 9:136
3. Pan M, et al. 2015. J Dermatol. 42:11-7

Publications