Product
Mouse Anti-Human CDK5 Monoclonal Antibody (CBP2401)
[CAT#: NAB2010432LS]
Anti-CDK5 Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Cyclin-dependent kinases (CDKs) are a family of Ser/Thr kinases known for their roles in the control of cell cycle progression. CDK5 is an atypical member in that it plays important roles in almost all aspects of brain development and function; it regulates multiple players required for axon formation and regeneration. CDK5 functions as a "plastic" kinase that maintains the axon growth ability by enabling efficient cytoskeletal reorganization, enhancing protein translation, reducing protein degradation, and promoting injury-induced gene transcription. Over-activation of CDK5 is associated with many neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Furthermore, CDK5 is reportedly involved in T cell activation and plays an important role in development of autoimmune disorders such as multiple sclerosis.
Immunogen
Purified recombinant fragment (aa 120-292) of human CDK5 expressed in E.coli.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1, κ
Clone Number
CBP2401
Applications
WB
Application Notes
WB (0.5-2.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Handling Advice
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
CDK5
Official Name
CDK5
Full Name
Cyclin Dependent Kinase 5
Alternative Names
Cyclin Dependent Kinase 5; Serine/Threonine-Protein Kinase PSSALRE; Tau Protein Kinase II Catalytic Subunit; Cell Division Protein Kinase 5; TPKII Catalytic Subunit; Cyclin-Dependent-Like Kinase 5; Protein Kinase CDK5 Splicing;
References
1. Wilkaniec A, et al. 2015. J. Neurochem. 10.1111/jnc.13365.
2. Liu SL, et al. 2015. Mol. Neurobiol.
3. Lai KO, et al. 2015. Mini. Rev. Med. Chem. 15:390.
4. Ye T, et al. 2012. Int. Rev. Neurobiol. 105:91.
5. Cheung ZH, et al. 2012. Trends Cell Biol. 22:169.
6. Lalioti V, et al. 2010. Cell Cycle 9:284.
7. Slevin M, et al. 2009. Curr. Opin. Pharmacol. 9:119.
8. Dhavan R, et al. 2001. Nat. Rev. Mol. Cell. Biol. 2:749.
9. Pareek TK, et al. 2010. J. Exp. Med. 207:2507.
2. Liu SL, et al. 2015. Mol. Neurobiol.
3. Lai KO, et al. 2015. Mini. Rev. Med. Chem. 15:390.
4. Ye T, et al. 2012. Int. Rev. Neurobiol. 105:91.
5. Cheung ZH, et al. 2012. Trends Cell Biol. 22:169.
6. Lalioti V, et al. 2010. Cell Cycle 9:284.
7. Slevin M, et al. 2009. Curr. Opin. Pharmacol. 9:119.
8. Dhavan R, et al. 2001. Nat. Rev. Mol. Cell. Biol. 2:749.
9. Pareek TK, et al. 2010. J. Exp. Med. 207:2507.
Publications
Publications (0)
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
